@article{oai:oka-pu.repo.nii.ac.jp:00002402,
 author = {Ma, Yun and Ma, Yun and Maruta, Hitomi and 丸田, ひとみ and Sun, Baojun and Yamashita, Hiromi and 山下, 広美},
 journal = {岡山県立大学保健福祉学部紀要, BULLETIN OF FACULTY OF HEALTH AND WELFARE SCIENCE, OKAYAMA PREFECTURAL UNIVERSITY},
 month = {Mar},
 note = {As the aging population grows worldwide,the importance of research on aging and agerelated changes is emerging. Aging, as an inevitable process, could lead to physiological functional declines in metabolic, respiratory, and exercise capacity, and could be associated with many diseases. In this study,we examined age-related changes,including O2 consumption volume (VO2), spontaneous locomotor activity,tissue weight, blood biochemical index, and gene expression in skeletal muscle of Sprague-Dawley (SD) rats,aged 32 to 92 weeks. Our findings suggest that the aging process might contribute to a decline in the VO2,spontaneous locomotor activity, and glucose oxidation of rats aged 90 weeks compared to that of rats aged
32 weeks. With advancing age, skeletal muscle mass decreased significantly in rats aged 85 weeks (soleus muscle: 0.47 g/kg, gastrocnemius (Gas) muscle: 5.00 g/kg), and 92 weeks (soleus muscle: 0.50 g/kg, Gas muscle: 5.62 g/kg) compared to that in rats aged 32 weeks (soleus muscle: 0.70 g/kg, Gas muscle: 8.89 g/kg).With aging, the levels of genes Myh7, pargc1α, Cycs, and sdha, and mitochondrial DNA, which are related to skeletal muscle function and muscle oxidative capacity, decreased significantly in the soleus muscle of rats aged 85 and 92 weeks compared to that of rats aged 32 weeks. In addition, lipid accumulation in skeletal muscle and weight of white adipose tissue (WAT) around kidney increased with age in rats. This study may clarify age-related changes in energy metabolism, skeletal muscle characteristics, and lipid accumulation in rats, and provide a potential perspective for anti-aging research., P(論文)},
 pages = {83--92},
 title = {Age-related changes in energy metabolism and skeletal muscle function of Sprague-Dawley rats},
 volume = {27},
 year = {2021}
}