{"created":"2023-06-19T07:56:08.111283+00:00","id":539,"links":{},"metadata":{"_buckets":{"deposit":"25ce8279-fd84-4ca5-bf0e-79fe26a6cfb7"},"_deposit":{"created_by":19,"id":"539","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"539"},"status":"published"},"_oai":{"id":"oai:oka-pu.repo.nii.ac.jp:00000539","sets":["15:47:149"]},"author_link":["3369","3370","3373","3371","3374","3362","3375","3372","3442","3376","3367","3368"],"item_10002_alternative_title_24":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"セイリカッセイシシツゴウセイケイ ヲ ターゲット トシタ ジネンジョ ガンユウショク ノ ショクヒン キノウセイ ノ カイセキ"}]},"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"43","bibliographicPageStart":"37","bibliographicVolumeNumber":"20","bibliographic_titles":[{"bibliographic_title":"岡山県立大学保健福祉学部紀要"},{"bibliographic_title":"Bulletin of Faculty of Health and Welfare Science, Okayama Prefectural University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヤマノイモ科に属する自然薯（Dioscorea japonica）は、含有するムチンによる胃粘膜保護やアミラーゼによる消化促進作用を有することが知られている。また、滋養強壮、老化防止、更年期障害の予防や神経保護作用などを有することが期待されてきたが、これらの機能性については科学的な根拠が十分ではない。本研究では、自然薯の生理活性脂質合成系をターゲットとした食品機能性を探索するために、マウスの自然薯粉含有食経口摂取による血清中ステロイドホルモン濃度の変化と脳内のステロイド合成系酵素ならびにプロスタグランジン（PG）E2 合成系酵素の発現動態について解析した。その結果、デヒドロエピアンドロステロン（DHEA）とコルチゾールの血清濃度上昇が認められた。さらに、ステロイド合成系酵素の17 β - ヒドロキシステロイドデヒドロゲナーゼ（17 β -HSD）、アロマターゼ（P450arom）、17 α - ヒドロキシラーゼ（P450c17）と、PGE2 合成系酵素のシクロオキシゲナーゼ（COX-1、COX-2）とPGE2 合成酵素（mPGES-1、cPGES）の発現が抑制された。本研究結果より、マウス経口摂取において、自然薯は、DHEA やコルチゾールの上昇、PGE2 合成抑制作用を有することが示唆された。これにより、自然薯による神経保護や抗炎症効果が期待される。","subitem_description_type":"Abstract"}]},"item_10002_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Dioscorea japonica is one of wild yams and is a relative of the Dioscoreaceae family. For many years, it is believed that Dioscorea japonica is good for a nutritional fortification and has some effects of gastric mucosal protection, digestive enhancement and so on. In some areas, the wild yam has been used as folk medicine against asthma, rheumatoid arthritis, bronchitis, and other diseases. However, the detailed physiological effects of the yam have not been clear. In the present study, we focus on the functional effects of Dioscorea japonica on bioactive lipid synthesizing enzymes. The diet containing 10%(W/W) Dioscorea japonica powder was orally ingested to the mouse. Dioscorea japonica increased the concentration of dehydroepiandrosterone and cortisol in the mouse serum. Dioscorea japonica suppressed mRNA expression of 17β-hydroxysteroid dehydrogenase, aromatase and 17α-hydoxylase/17,20-lyase in steroid synthesis pathway, and that of COX-1, COX-2, mPGES-1 and cPGES in prostaglandin E2 synthesis pathway in the mouse brain. Thus Dioscorea japonica may have a role in neuroprotection and anti-inflammation via the regulation of bioactive lipid synthesis in the mouse.","subitem_description_type":"Other"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15009/00000532","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"岡山県立大学保健福祉学部"}]},"item_10002_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"120005397778","subitem_relation_type_select":"NAID"}}]},"item_10002_select_1":{"attribute_name":"ページ属性","attribute_value_mlt":[{"subitem_select_item":"P(論文)"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN10488896","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13412531","subitem_source_identifier_type":"ISSN"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山本(鈴木), 登志子(登志子)"},{"creatorName":"山本(鈴木), 登志子(登志子)","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"田中, 小百合"}],"nameIdentifiers":[{},{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"津嘉山, 泉","creatorNameLang":"ja"},{"creatorName":"ツカヤマ, イズミ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"津嘉山","familyNameLang":"ja"},{"familyName":"ツカヤマ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"泉","givenNameLang":"ja"},{"givenName":"イズミ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"大本, 安梨紗"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"吉尾, 壯兒"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"川上, 祐生"},{"creatorName":"Kawakami, Yuki","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"木本, 眞順美"},{"creatorName":"Kimoto, Masumi","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"高橋, 吉孝"},{"creatorName":"Takahashi, Yoshitaka","creatorNameLang":"en"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Tanaka, Sayuri","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tsukayama, Izumi","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Oomoto, Arisa","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yoshio, Soji","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2014-03-17"}],"displaytype":"detail","filename":"第20巻 A原著論文-5.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"第20巻 A原著論文-5","url":"https://oka-pu.repo.nii.ac.jp/record/539/files/第20巻 A原著論文-5.pdf"},"version_id":"d3bc1ab6-e135-4327-b8f8-1ab0d38399cc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"自然薯","subitem_subject_scheme":"Other"},{"subitem_subject":"ステロイド合成系酵素","subitem_subject_scheme":"Other"},{"subitem_subject":"プロスタグランジンE2 合成系酵素","subitem_subject_scheme":"Other"},{"subitem_subject":"Dioscorea japonica","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"steroid synthesizing enzymes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prostaglandin E2 synthesizing enzymes","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"生理活性脂質合成系をターゲットとした自然薯粉含有食の食品機能性の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"生理活性脂質合成系をターゲットとした自然薯粉含有食の食品機能性の解析"},{"subitem_title":"Food functionality of the diet containing Dioscorea japonica powder targeting bioactive lipid synthesis pathway","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"19","path":["149"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-03-12"},"publish_date":"2014-03-12","publish_status":"0","recid":"539","relation_version_is_last":true,"title":["生理活性脂質合成系をターゲットとした自然薯粉含有食の食品機能性の解析"],"weko_creator_id":"19","weko_shared_id":-1},"updated":"2023-07-31T05:00:30.422361+00:00"}