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Age-related changes in energy metabolism and skeletal muscle function of Sprague-Dawley rats
https://doi.org/10.15009/00002367
https://doi.org/10.15009/00002367576f7f91-3bd0-4957-b61a-fc7acc89c4c8
| 名前 / ファイル | ライセンス | アクション |
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第27巻 B原著-7 (2.1 MB)
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| Item type | 紀要論文（H26～） / Departmental Bulletin Paper(1) | |||||||||||||||||||
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| 公開日 | 2021-03-12 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Age-related changes in energy metabolism and skeletal muscle function of Sprague-Dawley rats | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | aging | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Sprague-Dawley rat | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | skeletal muscle | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | energy metabolism | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | lipid accumulation | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||||
| ID登録 | ||||||||||||||||||||
| ID登録 | 10.15009/00002367 | |||||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||||
| ページ属性 | ||||||||||||||||||||
| 言語 | ja | |||||||||||||||||||
| 値 | P(論文) | |||||||||||||||||||
| 著者 |
Ma, Yun
× Ma, Yun
× 丸田, ひとみ
× Sun, Baojun
× 山下, 広美
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | As the aging population grows worldwide,the importance of research on aging and agerelated changes is emerging. Aging, as an inevitable process, could lead to physiological functional declines in metabolic, respiratory, and exercise capacity, and could be associated with many diseases. In this study,we examined age-related changes,including O2 consumption volume (VO2), spontaneous locomotor activity,tissue weight, blood biochemical index, and gene expression in skeletal muscle of Sprague-Dawley (SD) rats,aged 32 to 92 weeks. Our findings suggest that the aging process might contribute to a decline in the VO2,spontaneous locomotor activity, and glucose oxidation of rats aged 90 weeks compared to that of rats aged 32 weeks. With advancing age, skeletal muscle mass decreased significantly in rats aged 85 weeks (soleus muscle: 0.47 g/kg, gastrocnemius (Gas) muscle: 5.00 g/kg), and 92 weeks (soleus muscle: 0.50 g/kg, Gas muscle: 5.62 g/kg) compared to that in rats aged 32 weeks (soleus muscle: 0.70 g/kg, Gas muscle: 8.89 g/kg).With aging, the levels of genes Myh7, pargc1α, Cycs, and sdha, and mitochondrial DNA, which are related to skeletal muscle function and muscle oxidative capacity, decreased significantly in the soleus muscle of rats aged 85 and 92 weeks compared to that of rats aged 32 weeks. In addition, lipid accumulation in skeletal muscle and weight of white adipose tissue (WAT) around kidney increased with age in rats. This study may clarify age-related changes in energy metabolism, skeletal muscle characteristics, and lipid accumulation in rats, and provide a potential perspective for anti-aging research. |
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| 言語 | en | |||||||||||||||||||
| 書誌情報 |
ja : 岡山県立大学保健福祉学部紀要 en : BULLETIN OF FACULTY OF HEALTH AND WELFARE SCIENCE, OKAYAMA PREFECTURAL UNIVERSITY 巻 27, p. 83-92, 発行日 2021-03-12 |
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| 出版者 | ||||||||||||||||||||
| 出版者 | 岡山県立大学保健福祉学部 | |||||||||||||||||||
| 言語 | ja | |||||||||||||||||||
| ISSN | ||||||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||||||
| 収録物識別子 | 13412531 | |||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AN10488896 | |||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
